Cetuximab-activated natural killer (NK) and dendritic cells (DC) collaborate to trigger tumor antigen-specific T cell immunity in head and neck cancer patients
نویسندگان
چکیده
Author Affiliations: 1 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 2 Biostatistics Facility, University of Pittsburgh Cancer Institute, Pittsburgh, PA 3 Department of Surgery, University of Pittsburgh, Pittsburgh, PA 4 Department of Pathology, University of Pittsburgh, Pittsburgh, PA 5 Department of Immunology, University of Pittsburgh, Pittsburgh, PA 6 Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA
منابع مشابه
Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
PURPOSE Tumor antigen-specific monoclonal antibodies (mAb) block oncogenic signaling and induce Fcγ receptor (FcγR)-mediated cytotoxicity. However, the role of CD8(+) CTL and FcγR in initiating innate and adaptive immune responses in mAb-treated human patients with cancer is still emerging. EXPERIMENTAL DESIGN FcγRIIIa codon 158 polymorphism was correlated with survival in 107 cetuximab-treat...
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